In consequence, there have been significant research efforts to diagnosis, treat and possibly prevent the disease progression. S National Institute of Health (NIH) attributes a cost of over $100 billion per year to AD and estimates that, with the current state of population dynamics, Alzheimer’s prevalence may triple within the next 30 years due the aging baby boom generation. More specifically, AD affects 3% of the population between 65 and 75 years of age and 47% of the population over 85 years. Currently, approximately 5.8 million Americans have been diagnosed with AD: 5.6 million individuals of age 65 and older and 200,000 individuals younger than age 65. The goal of our initial model is to ultimately guide further hypothesis refinement and experimental testing to better understand the dynamic system interactions present in the etiology and pathogenesis of AD.Īlzheimer’s Disease (AD) is a progressive, degenerative disease of the brain associated with dementia, mood instability and cognitive impairment. The model confirms current conclusions in available research but can be easily adjusted to match future evidence and be used by researchers for their own individual purposes. The modelling framework provides an organized visual representation of how AD progression may occur via the olfactory system to better understand disease pathogenesis. In contrast, higher immunities, correlated with younger individuals, demonstrated little to no such formation. Lower immunities, correlated with elderly individuals, had quicker and more Aβ plaque and NF tangle formation counts. Our model also indicated how mucosal and neural immunity can play a significant role in the pathway considered. pneumoniae can result in infection propagation and significant buildup of Aβ plaque and NF tangles in the olfactory cortex and hippocampus. Our initial simulations demonstrated that breathing in C. Resultsīased on the set of biological rules, simulated randomized infection by the microbe led to the formation of beta-amyloid (Aβ) plaque and neurofibrillary (NF) tangles as well as caused immune responses. The model maps the bacteria infecting cells from the nasal cavity and the olfactory epithelium, through the olfactory bulb and into the olfactory cortex and hippocampus regions of the brain. The objective of our initial model is to simulate one possible spatial and temporal pathway of bacterial propagation via the olfactory system, which may then lead to AD symptoms. Chlamydia pneumoniae) may play a role in late-onset AD. A novel agent-based modelling framework was developed in NetLogo 3D to provide fundamental insights into the potential mechanisms by which a microbe (eg. Netlogo 6.0-beta1 user manual: interface guide.Alzheimer’s disease (AD) is a degenerative brain disease. Netlogo dynamics system guide procedures tab. Netlogo dynamics system guide procedures tab NetLogo 6.2.0 User Manual: Extension Manager Guide Text tab info netlogo plain edit again unformatted editing done ccl northwestern docs edu NetLogo 3.0.2 User Manual: System Dynamics Guide Netlogo dynamics system guide code ccl northwestern docs edu causing element idea give better should which beta2 NetLogo 6.1.1 User Manual: Info Tab Netlogo system dynamics code beta1 predation sheep wolf integration step diagram ccl northwestern systemdynamics docs edu NetLogo 6.2.0 User Manual: System Dynamics Guide Interface settings netlogo beta1 guide pressing toolbar button editing accessible northwestern ccl docs edu tab NetLogo 6.0-BETA1 User Manual: System Dynamics Guide Netlogo births given NetLogo 6.0-BETA1 User Manual: Interface Guide Netlogo chart colors paint key pcolor type northwestern different shade types manual use space spacing important around NetLogo 5.3.1 User Manual: System Dynamics Guide Netlogo diffuse NetLogo 5.1.0 User Manual: Tutorial #2: Commands ![]() ![]() NetLogo User Manual: Tutorial #3: Procedures 9 Pics about NetLogo User Manual: Tutorial #3: Procedures : NetLogo 6.0-BETA1 User Manual: System Dynamics Guide, NetLogo 5.3.1 User Manual: System Dynamics Guide and also NetLogo 3.0.2 User Manual: System Dynamics Guide. NetLogo User Manual: Tutorial #3: Procedures.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |